The two neuropathological hallmarks of Alzheimer’s disease (AD) are the extracellular aggregation of amyloid-beta peptides in the brain to form amyloid plaques and the aggregation of tau proteins to form neurofibrillary tangles in neurons. The fellow will be part of a project that will characterize the structures of amyloid-beta fibrils and tau tangles in AD using small angle x-ray scattering (SAXS) technique. Towards this effort, the fellow will design protein aggregation protocols mimicking various aggregation states of amyloid-beta and tau in AD and perform structure characterization of those aggregates at different length scales.
Participant Learning Objectives:
• The participant will gain hands-on experience to perform experimental measurements to characterize protein aggregates using SAXS.
• The participant will gain experience with protein modifications to form protein aggregates associated with Alzheimer’s disease and characterize them at different length scales.
To apply for this job please visit www.zintellect.com.